Reverse engineering cortical circuits
See also our profile on google scholar.
Vervaeke K. , Peron S., Magee J., Svoboda K. A comprehensive study of neural inhibition in the somatosensory cortex during tactile sensation.
Manuscript in progress
Right figure: We trained mice to report the location of an object and mapped the activity of all the major classes of inhibitory
neurons in the barrel cortex
Bojarskaite L, Bjørnstad D, Pettersen KH, Cunen C, Hermansen, GH, Åbjørsbråten KS,
Chambers A, Sprengel R, Vervaeke K, Tang W, Enger R, Nagelhus EA. Ca2+ signaling in
astrocytes is reduced during sleep and is involved in the regulation of slow wave sleep.
Nature Communications, 2020.
Hu H, Vervaeke K. Synaptic integration in cortical inhibitory neuron dendrites.
Neuroscience, 2018 (Invited review for special issue on Barrel Cortex. In press)
Morland C, Andersson K, Haugen O, Hadzic H, Kleppa L., Gille A, Rinholm JE,
Palibrk V, Diget E, Kennedy L, Stolen T, Hennestad E, Moldestad O, Cai Y, Puchades M,
Offermans S, Vervaeke K, Bjoras M, Wisloff U, Storm-Mathisen J, Bergersen L.
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1.
Nature Communications, 2017
Enger R., Dukefoss D., Tang W., Pettersen K., Bjørnstad D., Helm PJ, Jensen V.,
Sprengel R., Vervaeke K., Ottersen OP, Nagelhus EA. (2017). Deletion of Aquaporin-4
Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in
Cerebral Cortex, 2017
Szoboslay, M.*, Lorincz A.*, Lanore F.*, Vervaeke K., Silver A., Nusser Z. (2016).
Functional properties of dendritic gap junctions in cerebellar Golgi cells.
Neuron, 2016 , Jun 1;90(5):1043-56.
Previewed by Pereda AE. The variable strength of electrical synapses.
Rinholm JE, Vervaeke K, Tadross M, Tkachuk AN, Brown TA, Bergersen LH
and Clayton DA. Movement and structure of mitochondria in oligodendrocytes
and their myelin sheaths.
Glia, 2016, May;64(5):810-25
Vervaeke, K, Lorincz, A, Nusser, Z, Silver, RA. Gap junctions compensate for sublinear
dendritic integration in an inhibitory network.
Science, 2012, Mar 30;335(6076)
Vervaeke, K, Lorincz, A., Gleeson, P., Farinella, M., Nusser, Z., and Silver, R.A..
Rapid desynchronization of an electrically coupled interneuron network with spa￼rse
Neuron, 2010, 67, 435-451.
Previewed by: Connors BW, Zolnik TA and Lee SC.
Enhanced functions of Electrical Junctions
Neuron, 2010, 67 (3) 354-356
Hu, H.*, Vervaeke, K.*, Graham, L.J., and Storm, J.F.. Complementary theta resonance filtering by two spatially segregated mechanisms in CA1 hippocampal
Journal of Neuroscience, 2009, 29, 14472-14483.
Gu, N., Hu, H., Vervaeke, K., and Storm, J.F.. SK (KCa2) channels do not control somatic excitability in CA1 pyramidal neurons but can be activated by dendritic excitatory synapses and regulate their impact.
Journal of Neurophysiology, 2008, 100, 2589-2604.
Hu, H., Vervaeke, K., and Storm, J.F.. M-channels (Kv7/KCNQ channels) that regulate synaptic integration, excitability, and spike pattern of CA1 pyramidal cells are located in the perisomatic region.
Journal of Neuroscience, 2007, 27, 1853-1867.
Gu, N., Vervaeke, K., and Storm, J.F.. BK potassium channels facilitate high-frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells.
Journal of Physiology, 2007, 580, 859-882.
Vervaeke, K.*, Hu, H.*, Graham, L.J., and Storm, J.F.. Contrasting effects of the persistent Na+ current on neuronal excitability and spike timing.
Neuron, 2006, 49, 257-270.
Vervaeke, K., Gu, N., Agdestein, C., Hu, H., and Storm, J.F.. Kv7/KCNQ/M-channels in rat glutamatergic hippocampal axons and their role in regulation of excitability and transmitter release.
Journal of Physiology, 2006, 576, 235-256.
Gu, N., Vervaeke, K., Hu, H., and Storm, J.F.. Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells.
Journal of Physiology, 2005, 566, 689-715.
Hu, H., Vervaeke, K., and Storm, J.F.. Two forms of electrical resonance at theta frequencies, generated by M-current, h-current and persistent Na+ current in rat hippocampal pyramidal cells.
Journal of Physiology, 2002, 545, 783-805.
Storm JF, Vervaeke K, Hu H, Graham LJ. (2008). Functions of the persistent Na+ current in cortical neurons revealed by dynamic clamp. “Dynamic clamp: from principles to applications”, Springer Verlag, Alain Destexhe and Thierry Bal.